Abstract #1774

A Quantitative Framework to Study MRI Related Treatment Changes in the Prostate Post-IMRT

Pallavi Tiwari¹, John Kurhanewicz², Anant Madabhushi¹

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; ²Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

In this work, we present an image analysis framework to quantiatively evaluate changes in strucutral, functional, and metabolic markers (obtained via T2-w, DWI, MRS respectively) to (a) identify MRI markers that correlate the most with treatment related changes post-radiation therapy (RT) in prostate cancer (CaP) patients, and (b) compute a weighted MP-MRI map by optimally combining contributions of strucutral (T2-w), functional (DWI), metabolic (MRS) markers, based on their ability to accurately capturing post-RT changes.