Abstract #1788

Spatially Matched in Vivo and ex Vivo MR Metabolic Profiles of Prostate Cancer Investigation of a Correlation with Gleason Score

Kirsten M. Selns¹,², Ingrid Susann Gribbestad¹,², Helena Bertilsson³,⁴, Alan Wright⁵, Anders Angelsen⁴, Arend Heerschap,¹⁵, May-Britt Tessem¹,²

¹Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; ²St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; ³Department of Laboratory Medicine and Children's and Women's Helath, Norwegian University of Science and Technology, Trondheim, Norway; ⁴Department of Urology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; ⁵Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

MR metabolic profiling of the prostate is promising as an additional diagnostic approach to separate indolent from aggressive prostate cancer. MR metabolite ratios (choline+creatine+spermine/citreate) obtained non-invasively from patients in vivo by magnetic resonance spectroscopic imaging (MRSI) and from tissue samples ex vivo by high resolution magic angle spinning (HR-MAS) MR spectroscopy (MRS) correlate to Gleason score (&[rho]=0.77 and &[rho]=0.69, respectively, p<0.001). There is also a strong positive correlation between metabolite ratios from in vivo and ex vivo MR spectra of matched regions.