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Abstract #1798

Comparison of Single and Multi-Compartment Models of Diffusion in Fixed Prostate Tissue

Eleftheria Panagiotaki1, Daniel C. Alexander2, Roger Bourne3

1Centre for Medical Image Computing, University College London, London, United Kingdom; 2Centre for Medical Image Computing, Dept Computer Science, University College London, London, United Kingdom; 3 Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia

This study used high-field high-gradient diffusion-weighted (DW) MRI of fixed prostate tissue to explore the key components of an accurate biophysical model for obtaining future biomarkers of cancer and other pathology. We acquired DW-MRI with a rich imaging protocol and selected for modelling two tissue types (from the central and peripheral zone ) to compare four diffusion models.