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Abstract #1799

Challenges in Spatial Correlation of Multiparametric MRI Sequences and Pathology Findings in Prostate Cancer Staging

Fiona M. Fennessy1, 2, Andriy Fedorov1, Tobias Penzkofer1, 3, Clare Tempany1

1Radiology, Brigham and Women's Hospital, Boston, MA, United States; 2Radiology, Dana Farber Cancer Institute, Boston, MA, United States; 3Radiology, RWTH Aachen University Hospital, Aachen, Germany

Spatial correlation and evaluation of the diagnostic accuracy of the mpMR sequences in prostate imaging is not trivial and not always feasible in patients undergoing a routine clinical evaluation mpMR prostate protocol and routine histology processing. This exhibit outlines the challenges in detailed correlation of pathology findings with individual mpMR sequences in prostate cancer staging. It underscores the need for a large clinical cohort, and makes audience aware of the limitations of mpMR correlation with routine histology/biopsy reports when prospective dedicated whole mount pathology is not available. This exhibit also underscores the need for further development and validation of imaging registration technology to facilitate development of mpMR as a biomarker for prostate cancer.