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Abstract #1820

Human Brain Cooling During Breath-Holding

Sbastien Murat1, Jan Weis1, Francisco Ortiz-Nieto1, Hkan Ahlstrm1

1Department of Radiology, Uppsala University Hospital, Uppsala, Sweden

Controversy exists as to whether humans are capable of brain-cooling under any circumstances. Based on previous animal experiments, evidence of brain cooling was sought during controlled breath-holding. MR phase-difference method was used for measurement of human brain temperature changes during breath-hold. Brain temperature promptly decreased by ca 1 C in 1 min. Indications are that humans can invoke extreme brain cooling to lower metabolic rate. The study opens-up new in-roads for potentially treating a wide range of critical illnesses (e.g., stroke, cardiac arrest, brain injury) avoiding the limitations of therapeutic hypothermia.