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Abstract #1822

Effect of Additional Anatomical Features of the Head from High Resolution 3D UTE Images on Focal Intensity and Location for Transcranial MR-Guided Focused Ultrasound Surgery

Urvi Vyas1, Ethan M. Johnson2, Michael Marx2, John M. Pauly2, Kim R. Butts Pauly1

1Radiology, Stanford University, Stanford, CA, United States; 2Electrical Engineering, Stanford University, Stanford, CA, United States

For transcranial MR-guided focused ultrasound surgery in the brain, CT based imaging is used currently for correcting for distortions in the location and shape of the beams focus due to heterogeneities of the cranium. In this work we use high resolution UTE images and 3D ultrasound beam simulations to demonstrate the effect of additional anatomical features of the head (skin, subcutaneous fat, galea aponeurotica, marrow) on the location and intensity of the focal zone. A 2 mm on-axis shift and a 20% decrease in the focal intensity is estimated using information from the UTE images.