Marcia Costa1, Carolina Fernandes1, Arik Hananel2, Matt Eames2, John Angle3, John P. Mugler, III3, Talissa A. Altes3, Jaime F. Mata3
1Institute of Biophysics and Biomedical Engineering, FCUL, Lisbon, Portugal; 2Focused Ultrasound Surgery Foundation, Charlottesville, VA, United States; 3Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States
The main aim of this study was to determine and to compare the feasibility of pleural mesothelioma debulking with Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA), in a swine model of mesothelioma. We were able to create a successful mesothelioma tumor model in pigs and study its characteristics in-vivo using Magnetic Resonance Imaging (MRI) and post-mortem during necropsy. Furthermore, it was possible to prove the feasibility of both techniques, as well as to investigate the best parameters to apply them in large animal. Therefore, it was as innovative study in mesothelioma tumor model development and treatment.