Abstract #1827

Cytoreductive Surgical Treatment of Pleural Mesothelioma: A Comparison Study Betweem Radiofrequency Ablation and MRgFUS Treatments in a Swine Model of Mesothelioma

Marcia Costa¹, Carolina Fernandes¹, Arik Hananel², Matt Eames², John Angle³, John P. Mugler, III³, Talissa A. Altes³, Jaime F. Mata³

¹Institute of Biophysics and Biomedical Engineering, FCUL, Lisbon, Portugal; ²Focused Ultrasound Surgery Foundation, Charlottesville, VA, United States; ³Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States

The main aim of this study was to determine and to compare the feasibility of pleural mesothelioma debulking with Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA), in a swine model of mesothelioma. We were able to create a successful mesothelioma tumor model in pigs and study its characteristics in-vivo using Magnetic Resonance Imaging (MRI) and post-mortem during necropsy. Furthermore, it was possible to prove the feasibility of both techniques, as well as to investigate the best parameters to apply them in large animal. Therefore, it was as innovative study in mesothelioma tumor model development and treatment.