Abstract #1828

Treatment of Staphylococcus Aureus Induced Abscesses Via Magnetic Resonance Guided Focused Ultrasound

David Bates¹,², Birgit Rieck¹, Laura Curiel¹,³, Samuel Pichardo¹,³

¹Thunder Bay Regional Research Institute, Thunder Bay, Ontario, Canada; ²Biology, Lakehead University, Thunder Bay, Ontario, Canada; ³Department of Electrical and Computer Engineering, Lakehead University, Thunder Bay, Ontario, Canada

MR-guided focused ultrasound was investigated as a mode of treatment for subcutaneous murine Staphylococcus aureus abscesses. High and moderate temperature ultrasonication of the abscess centre were investigated, with high temperature (65˚C) demonstrating a significantly reduced (p<.05) bacterial concentration with respect to control four days post-treatment. Neither level of treatment was shown to increase inflammation over the baseline elevated abscess activity, suggesting innate immune system sparing.