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Abstract #1829

Initial Experience with Volumetric MRI-Guided High-Intensity Focused Ultrasound Ablation in Breast Cancer Patients

Laura Merckel1, Roel Deckers2, Thijs van Dalen3, Max Khler4, Gerald Schubert4, Joost van Gorp5, Paul Vaessen6, Willem Mali1, Chrit T.W. Moonen2, Lambertus W. Bartels2, Maurice A.A.J. van den Bosch1

1Radiology, Univeristy Medical Center Utrecht, Utrecht, Netherlands; 2Images Sciences Institute, Univeristy Medical Center Utrecht, Utrecht, Netherlands; 3Surgery, Diakonessenhuis, Utrecht, Netherlands; 4Philips Heathcare, Vantaa, Finland; 5Pathology, Diakonessenhuis, Utrecht, Netherlands; 6Anesthesia, University Medical Center Utrecht, Utrecht, Netherlands

Our initial experiences with a dedicated MR-HIFU breast platform using a lateral and volumetric ablation technique are presented. In total, 10 breast cancer patients will be included. The study is performed according to a treat-and-resect protocol. In the first patient, it was difficult to perform a sonication due to problems with patient positioning and movement. In the second patient, three sonications were performed, causing tissue necrosis in the tumor observed during histopathological analysis. The PRFS-based optimized MR thermometry sequence had a temporal standard deviation of 1.86C after applying the multibaseline method to correct for temperature errors induced by respiration.