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Abstract #1860

in vivo Tracking of Ferumoxytol Labeled NK Cells Using MRI

Naomi Santa Maria1, Thomas Ng, Sharon Lin, Sarah McCaig2, Desiree Crow2, Jianyi Wang2, Andrew Raubitschek2, Russell E. Jacobs

1Biology, Caltech, Pasadena, CA, United States; 2City of Hope, Duarte, CA, United States

MRI can provide a noninvasive tool to characterize adoptive NK cell therapy. We aimed to implement MRI-based NK cell tracking methods that could be clinically translatable by using an FDA-approved USPIO cell label on NK cells isolated from human peripheral blood. MRI as a noninvasive in vivo cellular imaging technique could further elucidate optimization of adoptive NK cell transfer as a cancer therapy.