in vivo Tracking of Ferumoxytol Labeled NK Cells Using MRI

Naomi Santa Maria¹, Thomas Ng, Sharon Lin, Sarah McCaig², Desiree Crow², Jianyi Wang², Andrew Raubitschek², Russell E. Jacobs

MRI can provide a noninvasive tool to characterize adoptive NK cell therapy. We aimed to implement MRI-based NK cell tracking methods that could be clinically translatable by using an FDA-approved USPIO cell label on NK cells isolated from human peripheral blood. MRI as a noninvasive in vivo cellular imaging technique could further elucidate optimization of adoptive NK cell transfer as a cancer therapy.