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Abstract #1876

Curcumin/Gd Loaded Apoferritin: A Novel "Theranostic" Agent to Prevent Hepatocellular Damage in Models of Hepatic Injuries

Simonetta Geninatti1, Juan Carlos Cutrin1, Diana Burgelea1, Dario Livio Longo1, Walter Dastru1, Silvio Aime1

1Molecular Biotechnology and healt sciences, University of Torino, Torino, TO, Italy

Curcumin/Gd loaded Apoferritin is herein proposed as a new theranostic agent able to deliver simultaneously therapeutic and imaging probes to the liver. The incapsulation of curcumin inside the apoferritin cavity increases significantly its stability and bioavailability by maintaining its antioxidant and anti-inflammatory properties. Curcumin/Gd loaded Apoferritin was able to protect hepatocytes by the thiocetamide toxic action generating acute hepatitis injury.