Abstract #1875

Development of Targeted Paramagnetic Nanoparticle for Non-Invasive Tumor Imaging

Meser M. Ali¹, Nadimpalli RS Verma¹, Janic Branislava¹, James R. Ewing², Robert A. Knight², Ali S. Arbab¹

¹Radiology, Henry Ford Hospital, Detroit, MI, United States; ²Neurology, Henry Ford Hospital, Detroit, MI, United States

Water soluble membrane peptide (pHLIP) is conjugated with anionic dendrimer-based paramagnetic nanoparticle. pHLIP-tagged nanoparticles bind to and are internalized by breast cancer cells in vitro. Systemic delivery of dendrimer-based nanoparticles lead to accumulation of the nanoparticles in a flank mouse model of breast cancer that are detected by optical and MR imaging.