Miloslav Polasek1, Peter Caravan2
1Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, United States; 2Radiology, Massachusetts General Hospital, Charlestown, MA, United States
We explored a novel design of DOTA-like compounds where removal of an acetate arm on N1 is counterbalanced by a donor arm on N7. Surprisingly, presence of a non-coordinating moiety on N1 lowered kinetic stability of the Gd chelates. Choice of the donor arm on N7 influenced both kinetic stability and water exchange rate, the latter could be tuned over 2 orders of magnitude.