Abstract #1900

A Single Amino Acid Gd-Complex as a Modular Tool for High Relaxivity MR Contrast Agent Development.

Eszter Boros¹, Miloslav Polasek¹, Zhaoda Zhang¹, Peter Caravan²

¹Department of Radiology, Massachusetts General Hospital, Harvard Medical School, The Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States; ²Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States

We investigated applications of the alanine analogue of Gd(DOTA), Gd(DOTAla). Fmoc protected DOTAla suitable for solid phase peptide synthesis was synthesized and integrated into polypeptide structures containing 1-3 Gd(DOTAla) complexes (GdL1, GdL2, GdL3).GdL3 is superior to commercial contrast agents gadoteridol and gadofosveset /HSA (human serum albumin) at high fields. The modularity of design, the ease of solid phase synthesis, high kinetic inertness (t_1/2 = 614h) for Gd3, and optimal water exchange rate renders the Gd(DOTAla) scaffold a suitable platform for the development of high field T1 agents based on Gd.