MRI of 1H Long-Lived States Originated from ParaHydrogen Induced Polarization in Cs-Symmetric Molecules Using a Clinical MRI System

Dirk Graafen¹, ², Mara Beln Franzoni², Kerstin Mnnemann², Hans Wolfgang Spiess², Laura Maria Schreiber¹

The singlet state originated from parahydrogen induced polarization (PHIP) was stored inside the MRI scanner for minutes. After that time, it was converted to observable magnetization by generating singlet-triplet conversion. For this purpose, the Cs-symmetric molecule dimethyl maleate was used. In the present report it is shown that singlet-triplet conversion can be performed inside the observation field by applying a chemical shift scaling pulse sequence. The pulse sequence comprises of 80 cycles of eight 180 pulses and two characteristic delays. Moreover, a proton image was detected by using this conversion sequence prior every k-space line acquisition of a GRE sequence.