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Abstract #1921

MRI of 1H Long-Lived States Originated from ParaHydrogen Induced Polarization in Cs-Symmetric Molecules Using a Clinical MRI System

Dirk Graafen1, 2, Mara Beln Franzoni2, Kerstin Mnnemann2, Hans Wolfgang Spiess2, Laura Maria Schreiber1

1Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany; 2Max Planck Institute for Polymer Research, Mainz, Germany

The singlet state originated from parahydrogen induced polarization (PHIP) was stored inside the MRI scanner for minutes. After that time, it was converted to observable magnetization by generating singlet-triplet conversion. For this purpose, the Cs-symmetric molecule dimethyl maleate was used. In the present report it is shown that singlet-triplet conversion can be performed inside the observation field by applying a chemical shift scaling pulse sequence. The pulse sequence comprises of 80 cycles of eight 180 pulses and two characteristic delays. Moreover, a proton image was detected by using this conversion sequence prior every k-space line acquisition of a GRE sequence.