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Abstract #1929

Chemical Shift of 129Xe Is Dependent on Red Blood Cell Oxygenation

General Leung1, Graham Norquay1, Jan Wolber2, Jim M. Wild1

1Department of Cardiovascular Science, University of Sheffield, Sheffield, South Yorkshire, United Kingdom; 2GE Healthcare, Chalfont St Giles, Buckinghamshire, United Kingdom

Hyperpolarised 129Xe dissolves into various biological tissues and has a change in resonance frequency that is sensitive to its environment. The resonance frequency has previously been shown to be sensitive to red blood cell oxygen saturation and its use as an exogenous probe for MR oximetry is of interest. Here, we develop we develop a robust, quantitative relationship between oxygen saturation and chemical shift in vitro.