Markus Durst1, 2, Ulrich Kllisch1, 2, Francesca Frijia3, Luca Menichetti4, Maria Filomena Santarelli5, Massimo Lombardi3, Titus Lanz6, Matthias Mller6, Jan Henrik Ardenkjaer-Larsen7, Marion I. Menzel2, Axel Haase1, Rolf F. Schulte2
1Institute of Medical Engineering, Technische Universitt Mnchen, Garching, Germany; 2GE Global Research, Garching, Germany; 3Fondazione CNR-Regione Toscana G.Monasterio, Pisa, Italy; 4Institute of Clinical Physiology of CNR, Pisa, Italy; 5CNR Institute of Clinical Physiology, Pisa, Italy; 6Rapid Biomedical, Rimpar, Germany; 7GE Healthcare, Brndby, Denmark
Metabolic imaging of the heart following injection of hyperpolarised pyruvate could allow new methods for diagnosis and characterisation of heart disease. However, fast and efficient imaging sequences are required to adequately encode the information due to the rapidly decaying signal. Therefore, parallel imaging could be highly beneficial for in vivo metabolic imaging to speed up the acquisition process. In this work, an efficient autocalibrated single-shot spiral parallel imaging sequence for metabolic imaging of hyperpolarised compounds is presented. It is demonstrated that parallel imaging enables single-shot dynamic hyperpolarised imaging of the pig heart, which is an important step towards human studies.