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Abstract #1944

Age-Related Metabolite Alterations in Adolescents with High Functioning Autism, an 1H-MRS Study

Evelien M. Barendse1, Albert P. Aldenkamp1, Roy PC Kessels2, Marc P.H. Hendriks2, Geert Thoonen1, Paul A.M. Hofman3, Walter H. Backes3, Jacobus F.A. Jansen3

1Epilepsy Centre Kempenhaeghe, Heeze, NB, Netherlands; 2Neuropsychology, Radboud University Nijmegen, Nijmegen, Ge, Netherlands; 3Radiology, Maastricht University Medical Center, Maastricht, Li, Netherlands

In this cross-sectional study, we investigate the effect of age and intelligence on occipital metabolite concentrations in adolescents (aged 13-19y) with high functioning autism (HFA) and healthy controls. We observed that 1H-MRS provides evidence of atypical membrane metabolism development in HFA, which potentially underlies the observed atypical behavioral development in autism.