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Abstract #1945

Neurochemical Changes in Rat Brain After 5-Fluorouracil Chemotherapy Assessed by 1H MR Spectroscopy at 9.4 T

Ryutaro Nakagami1, 2, Masayuki Yamaguchi1, Yoshifumi Abe3, Tatsuhiro Hisatsune3, Akira Furukawa2, Hirofumi Fujii1

1Division of Functional Imaging, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; 2Graduate School of Health Sciences, Tokyo Metropolitan University, Arakawa-ku, Tokyo, Japan; 3Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan

Recent studies have reported that some cancer patients who received chemotherapy experienced mild cognitive impairment. Although the mechanism of this type of cognitive impairment is not fully understood, preliminary studies suggested that chemotherapy may induce neurotransmitter deficits, damaging cognitive function. Investigation of brain metabolite changes using in vivo MR spectroscopy may help to understand the mechanism of chemotherapy-induced cognitive impairment. In this study, we assessed metabolite changes in the brains of rats that received 5-FU (100 mg/kg) chemotherapy using 1H MR spectroscopy at 9.4 Tesla.