S. Bawden1, Mary C. Stephenson1, Elisabetta Ciampi2, J. Lane2, Luca Marciani3, P Morris1, I MacDonald4, Guru P. Aithal4, K. Hunter2, Penelope A. Gowland1
1SPMMRC, University of Nottingham, Nottingham, Notts, United Kingdom; 2Unilever Discover, Bedford, Beds, United Kingdom; 3NDDC Biomedical Research Unit, University of Nottingham, Nottingham, Notts, United Kingdom; 4Medical School, University of Nottingham, Nottingham, Notts, United Kingdom
This study investigates the lower limits of sensitivity in measuring changes in hepatic glycogen levels following an oral glucose challenge using in vivo natural abundance Carbon-13 MR spectroscopy. Subjects were scanned following an overnight fast for baseline values and then hourly for five hours following either a 50g glucose dose or control using a multi-nuclear surface coil. Spectra glycogen peak areas over the timecourse were compared between groups. Changes in gastric content and liver volume we also monitored to consider other related effects. Results show that hepatic glycogen AUCs were significantly higher in the glucose challenge group compared with control.