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Abstract #1960

In Vivo Magnetic Resonance Spectroscopy of Lipid Handling in Steatotic Rat Liver

Sharon M. Janssens1, Richard AM Jonkers1, Mattijs Heemskerk2, Sjoerd A. van den Berg2, Ko Willems van Dijk2, Natal A. van Riel, Klaas Nicolay1, Jeanine J. Prompers1

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands; 2Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands

Hepatic steatosis is het abnormal and excessive accumulation of triglycerides in the liver and is a hallmark of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to determine differences in in vivo lipid metabolism in steatotic livers of rats on different high-fat diets using 1H MRS with 13C editing in combination with the oral administration of 13C-labeled lipids. Animals on a high-fat diet developed liver steatosis accompanied by a significantly reduced lipid turnover in the liver.