Abstract #1961

Human Studies of Functional MRS at 7T with Semi-LASER

Petr Bednarik¹,², Ivan Tkac¹, Andrea Grant¹, Uzay E. Emir¹, Dinesh K. Deelchand¹, Silvia Mangia¹

¹CMRR - Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States; ²Molecular and Functional Imaging Laboratory, , CEITEC - Central European Institute of Technology, Masaryk University, , Brno, Czech Republic

In the present work we measured brain metabolite concentrations during a visual stimulation paradigm at 7 T with a full-intensity 1H MRS sequence, semi-LASER. In excellent agreement with our previous findings obtained with STEAM sequence, we observed significant concentration changes within ± 0.2 µmol/g for lactate, glutamate, aspartate and glucose. However, we could not detect changes in glutathione, glycine, glutamine and GABA as reported in other studies, despite higher MRS sensitivity. We conclude that the latter concentration changes are likely to be ascribed to the particular settings of the visual stimulation paradigm.