Richard AM Jonkers1,
Sharon M. Janssens1, Klaas Nicolay1, Luc JC van Loon2,
Jeanine J. Prompers1
1Biomedical
Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Department
of Human Movement Sciences, Maastricht University Medical Centre+,
Maastricht, Netherlands
Insulin resistance has been associated with ectopic lipid accumulation. Physical activity improves insulin sensitivity, but the impact of exercise on lipid handling in insulin-resistant skeletal muscle and liver remains to be elucidated. The present study characterizes postprandial lipid handling in liver and muscle of healthy and diabetic rats after one hour of treadmill running using in vivo 13C-edited 1H-MRS in combination with 13C-labeled lipid administration. We showed that muscle but not liver lipid stores represent a viable substrate source during exercise in healthy and diabetic rats. However, postprandial lipid uptake in liver and muscle was not affected by prior exercise.