Neuronal and Astroglial Metabolism in APP-PS1 Mouse Model of Alzheimer's Disease with Progress of Age

Vivek Tiwari¹, Pandichelvam Veeraiah¹, Anant Bahadur Patel¹

Alzheimer's disease (AD) is associated with deficit and dysfunction of neurotransmitters and synapses. Cerebral metabolic fluxes were measured in APP-PS1 mouse model of AD with the progress of age by using ¹H-[¹³C]-NMR spectroscopy in conjunction with infusion of ¹³C labeled glucose and acetate. APP-PS1 mice exhibit normal neurochemical profile and cerebral metabolism at very early age. At the preclinical age, neuronal metabolism is found to be impaired without any change in the level of neurometabolites. In addition to impaired neuronal metabolism and neurochemical profile, the APP-PS1 mice exhibit higher astroglial activity at the late age of the disease.