Simultaneous In Vivo 1H and 31P MRS Acquisition in Ischemic Rat Brain at Ultrahigh Field

Jennifer M. Taylor¹, ², Xiao-Hong Zhu², Yi Zhang², Wei Chen, ¹²

The information gained from a single MR spectroscopy (MRS) scan using conventional acquisition strategies is limited by the inability to acquire signal from multiple nuclei simultaneously. We propose a new MR acquisition configuration to allow for simultaneous acquisition of localized spin echo ¹H and global single pulse ³¹P MRS. We show this techniques feasibility for monitoring the alteration in cerebral metabolic and hemodynamic activities during an acute global forebrain ischemia in rat. This technique increases single measurement information and allows the exploration of the dynamic relationship among various metabolic and/or hemodynamic activities in animal or human under different physiopathological conditions.