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Abstract #2005

Separation and Precise Estimation of Glutamate and Glutamine Using Spectroscopic Imaging in Human Brain at 3.0 T

Sandeep Ganji1, Changho Choi2

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

We report in vivo spectroscopic imaging of glutamate and glutamine at 3T using an optimized echo-time PRESS-based localization method. Using our technique we achieved separation of Glu (2.35 ppm) and Gln (2.45 ppm) signals. The Gln concentration showed significant regional variation over the brain, with higher levels in gray matter dominant regions compared to white matter dominant regions. Higher concentrations of N-Acetylaspartylglutamic acid (NAAG) were well correlated with white matter dominant regions. Scan/rescan were performed in six healthy volunteers and reproducibility results are presented.