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Abstract #2011

1H-MRS in the in Vivo Mouse Heart: A Comparison Between PRESS and STEAM

Adrianus J. Bakermans1, Desiree Abdurrachim1, Klaas Nicolay1, Jeanine J. Prompers1

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands

Proton MR spectroscopy (1H-MRS) allows for the noninvasive detection of myocardial metabolites, but its application in preclinical studies has been limited. We assessed the suitability of PRESS and STEAM for 1H-MRS in the in vivo mouse heart. Both sequences were ECG-triggered and respiratory-gated. To maintain steady state of magnetization, dummy pulses were performed during respiratory gates. Water signal stability was slightly better for PRESS than for STEAM, and SNR for PRESS was two-fold higher compared to STEAM. Using PRESS-localized saturation recovery experiments, T1 values were determined for mouse myocardial water and triglyceride.