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Abstract #2032

Extraction of Glutamate from the GABA Edited Spectra

Jan Willem C. van der Veen1, Ron de Beer2, Dirk van Ormondt2, Jun Shen1

1Magnetic Resonance Spectroscopy Core, NIH, NIMH, Bethesda, MD, United States; 2Department of Applied Physics, TU Delft, Delft, Netherlands

It is desirable to simultaneously measure glutamate and GABA in many clinical studies. Here we used full density matrix simulation to investigate the effects of GABA editing on the J evolution of glutamate, glutamine and NAA at 3 Tesla. It was found the editing pulse and spectra subtraction significantly reduced overlap of glutamate by glutamine and NAA, making it possible to extract glutamate using linear combination spectral fitting of the edited GABA spectra.