Byeong-Yeul Lee1, Xiao-Hong Zhu1, Wei Chen1, Melissa Terpstra1
1Center for Magnetic Resonance Research (CMRR), Radiology Department, University of Minnesota, Minneapolis, MN, United States
Human brain ultra-high field (7T) scanners are increasingly available in clinical settings and advantageous for sensitivity and specificity. Accurate quantification of metabolite concentrations from 1H MRS requires appropriate partial volume correction, especially when studying treatment effect or pathologies that alter brain morphometry. We developed a tissue segmentation method that remained reliable in the presence of inhomogeneous B1, which is typically encountered at ultra-high field. Utilization of T1/PD ratio images improved histogram based classification of tissue types. Using this approach to correct for partial volume effects, test-retest repeatability of metabolite concentrations quantified from single voxel in vivo 1H-MRS was improved.