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Abstract #2038

Localization Profile Correction for ERETIC Based in Vivo 1H MRSI Quantification

Niklaus Zoelch1, Alexander Fuchs1, Anke Henning2, 3

1Institue for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland; 2Institue for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 3Max Planck Institue for Biological Cybernetics, Tbingen, Germany

ERETIC is a calibration method independent of the disease state, automatically compensates for changes in coil loading conditions and hence requires only a one time calibration against a high precision phantom. However, when ERETIC is used for the quantification of MRSI images, the combined effect of B1+ inhomogeneity across the volume of interest and slice profiles of the selective RF pulses used for localization need to be corrected for. In this work two approaches of this correction are presented and validated against internal water referencing.