Abstract #2067

Clinical Feasibility of High-Resolution Single-Shot Diffusion Tensor Trace -Weighted (SsTW) MRI

Alexandru V. Avram¹, Joelle E. Sarlls², Raisa Z. Freidlin³, Peter J. Basser¹

¹Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United States; ²National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; ³Division of Computational Bioscience, CIT, National Institutes of Health, Bethesda, MD, United States

Given the clinical importance of the mean apparent diffusion coefficient (ADC), we revisit strategies for measuring this important parameter in a single scan and propose an optimized solution for achieving high-resolution diffusion tensor trace -weighted imaging with whole brain coverage. Mean ADC maps measured using the proposed method are similar to those obtained using conventional diffusion tensor imaging (DTI), despite the significant scan time reduction. This technique could be uniquely suited to provide a quantitative microstructural assessment in whole-brain and whole-body diffusion MRI applications where motion is problematic.