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Abstract #2096

Histological Correlation of DKI-White Matter Modeling Metrics in the Cuprizone-Induced Corpus Callosum Demyelination

Maria F. Falangola1, 2, David Guilfoyle3, Edward S. Hui1, Xingju Nie1, Ali Tabesh1, Jens H. Jensen1, Scott Gerum4, Caixia Hu4, John LaFrancois4, Heather Collins1, Joseph A. Helpern1, 2

1Radiology and Radiological Science, Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States; 2Neurosciences, Medical University of South Carolina, Charleston , SC, United States; 3Nathan Kline Institute, Orangeburg,, NY, United States; 4Nathan Kline Institute, Orangeburg, NY, United States

The goal of this study was to utilize a recently developed white matter modeling method compatible with diffusional kurtosis imaging to characterize the demyelination process in the corpus callosum of the cuprizone mouse model. We studied 10 cuprizone and 10 control mice for a period of 10 weeks. All diffusion metrics were derived from DKI datasets. Quantitative analysis of myelin density was performed using Solochrome staining. The histological correspondence shown in our results demonstrate the correspondence between the WMM metrics and a well established histological marker of myelin.