Erin K. Englund1, Michael C. Langham1, Cheng Li1, Felix W. Wehrli1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States
In this work, a traditional pulsed arterial spin labeling (PASL) technique is combined with simultaneous image refocusing (SIR) EPI readout to measure dual-slice perfusion in the leg. PASL-SIR is evaluated by comparing results acquired in the two slices to an otherwise identical single-slice PASL sequence during a series of ischemia reperfusion paradigms in the leg. Time course parameters for the dual-slice PASL-SIR technique are in relative agreement with single-slice-measured perfusion and with literature reported values. Implementation of PASL-SIR in longitudinal studies may improve reproducibility by reducing errors due to subject repositioning.