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Abstract #2162

Comparison of Water Excitation Versus Fat Saturation in Perfusion MRI - Effects on Lipid Signal, SNR and CBF

Karthik Prabhakaran1, Ryan D. Hopson1, Mark A. Elliott1, Kosha Ruparel1, Raquel E. Gur1, Ruben C. Gur1, John A. Detre1

1University of Pennsylvania, Philadelphia, PA, United States

The use of frequency-selective fat saturation in EPI based perfusion imaging results in spurious measurements of cerebral blood flow (CBF) if the lipid suppression is poor and inconsistent. Frequency-selective water excitation provided superior lipid suppression and yielded higher CBF measurements when compared to frequency-selective fat-saturation in a spin-echo EPI pseudo-continuous arterial spin labeling (pCASL) application at 3T.