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Abstract #2170

A Two-Stage General Kinetic Model for Improved Estimation of Brain Tumour Perfusion Using Arterial Spin Labeling

Patrick W. Hales1, Kim P. Phipps2, Ramneek Kaur1, Tina Banks3, Christopher A. Clark1

1Imaging and Biophysics, University College London, London, United Kingdom; 2Neuro-oncology Department, Great Ormond Street Hospital, London, United Kingdom; 3Radiology Department, Great Ormond Street Hospital, London, United Kingdom

A two-stage model for quantification of CBF and arterial volume fraction in dynamic ASL data is presented. The two-stage model provides CBF values in healthy grey matter that are more in line with previously published data from PET studies (compared to standard single stage ASL models), due to a reduction in large vessel artefacts. Furthermore, the two-stage model is shown to provide a better fit to data collected in paediatric brain tumour patients, and provide novel contrast, in terms of arterial volume maps in and around the tumour region.