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Abstract #2171

Correlation Between PCASL and DSC Perfusion MRI with and Without Contrast Agent Leakage Correction in Brain Tumors

Feng-Xian Yan1, Alex M. Wong2, Ho-Ling Liu1, 2

1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 2Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

This study aimed to evaluate whether pseudo-continuous ASL (PCASL) perfusion method is sensitive to leaky vessels in brain tumors by comparing with DSC-MRI with and without leakage correction. Eight patients with contrast-enhancing tumors participated in this study. The results demonstrated that tumor/white matter (WM) CBF ratios obtained from PCASL had significant positive correlation with the leakage-corrected tumor/WM CBV ratios obtained from DSC-MRI(p=0.01), but not with the CBV ratios before correction(p=0.13). This study provides a direct evidence for supporting that using PCASL for evaluation of brain tumor perfusion is advantageous because it is insensitive to contract agent extravasation from tumor vessles.