Esther A H Warnert1, Ashley D. Harris1, Kevin Murphy1, Michael A. Chappell2, Judith E. Hall3, Richard G. Wise1
1Cardiff University Brain Research Imaging Centre, Cardiff, South Glamorgan, United Kingdom; 2University of Oxford, Headington, Oxford, United Kingdom; 3Department of Anaesthetics, Intensive Care and Pain Medicine, School of Medicine, Cardiff, South Glamorgan, United Kingdom
We have performed a multi-inversion time pulsed ASL study with healthy subjects to obtain tissue perfusion kinetic curves of the brainstem. A two-compartment model was used that contains a tissue and intra-arterial component in order to model out macrovascular signal. Our study showed that the brainstem perfusion signal indeed has a relatively high macrovascular component, which can be model out to obtain tissue perfusion curves.