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Abstract #2183

Effect of Deep Isoflurane Anesthesia on Cerebral Blood Flow Autoregulation in Non-Human Primates

Chun-Xia Li1, Sudeep Patel1, Danny J.J. Wang2, Xiaodong Zhang1

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; 2Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, United States

Non-human primates were widely used as various disease models in neuroscience studies and examined under isoflurane anesthesia. It is known that the cerebral blood flow (CBF) autoregulation can be disrupted under high isoflurane dosage and is more vulnerable in subcortical regions, but the regional specification of the effect remains poorly understood. In the present study, the pseudo continuous arterial-spin-labeling (pCASL) technique was used to evaluate the dose-dependent effect of deep isoflurane anesthesia on CBF of different brain structures. The result indicates that the CBF autoregulation in most cortical and subcortical regions of monkeys is impaired under 2% isoflurane.