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Abstract #2185

Assessment of Microcirculation in Murine Myocardium: A Retrospective Method for Quantification of Perfusion and Regional Blood Volume

Fabian Tobias Gutjahr1, Thomas Kampf1, Xavier Helluy1, Christian Herbert Ziener2, Peter M. Jakob1, 3, Wolfgang Rudolf Bauer4

1Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; 2German Cancer Research Center, Heidelberg, Baden Wuerttemberg, Germany; 3Magnetic Resonance Bavaria, Wuerzburg, Bavaria, Germany; 4Medizinische Klinik und Polyklinik I, Universitaetsklinikum Wuerzburg, Wuerzburg, Bavaria, Germany

In this work a retrospectively triggered method for the quantification of perfusion and regional blood volume (RBV) in murine myocardium is demonstrated. Perfusion and RBV maps can be reconstructed on any desired position in the heart cycle. Furthermore the calculation of RBV maps requires a voxel by voxel comparison of a pre and post contrast agent T1 map. A good match for both map can be guaranteed due to the ability to reconstruct T1 maps of any desired position in the heart cycle.