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Abstract #2186

Simultaneous Quantification of Perfusion, Venous Oxygen Saturation, and Skeletal Muscle T2* in Response to Cuff-Induced Ischemia in the Leg

Erin K. Englund1, Michael C. Langham1, Cheng Li1, Emile R. Mohler2, Thomas F. Floyd3, Felix W. Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Cardiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department of Anesthesiology, Stony Brook University, Stony Brook, NY, United States

A novel method to simultaneously measure perfusion, venous oxygen saturation, and skeletal muscle T2* using an interleaved pulsed arterial spin labeling and multi-echo GRE sequence, termed PASL/Ox-BOLD, is presented. The technique is assessed in healthy subjects during a series of ischemia reperfusion paradigms. Time course data is analyzed to investigate the kinetics of recovery following cuff-induced ischemia. Results indicate that PASL/Ox-BOLD is capable of faithfully measuring all three parameters at 2 second temporal resolution. The method is also used to investigate a small cohort of peripheral artery disease patients. In these patients, a blunted and delayed hyperemic response is detected.