Abstract #2198

Calibration of Dynamic Susceptibility Contrast MRI Using T1-Based Steady-State CBV (Bookend Technique) and Vascular Space Occupancy (VASO): Comparison with Pseudo-Continuous Arterial Spin Labeling

Emelie Lindgren¹, Ronnie Wirestam¹, Karin Markenroth Bloch¹,², Andr Ahlgren¹, Matthias J.P. van Osch³, Danielle van Westen⁴, Yulia Surova⁵,⁶, Freddy Sthlberg¹,⁷, Linda Knutsson¹

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden; ²Clinical science, Philips, Lund, Sweden; ³C.J.Gorter Center for high field MRI, Department of Radiology, LUMC, Leiden, Netherlands; ⁴Center for Medical Imaging and Physiology, Skane University Hospital Lund, Lund, Sweden; ⁵Department of Clinical Sciences, Lund University, Lund, Sweden; ⁶Department of Neurology, Skne University Hospital, Lund, Sweden; ⁷Lund University Bioimaging Centrum, Lund University, Lund, Sweden

Quantification of CBF in absolute terms is relevant in some clinical applications. However, absolute CBF obtained by dynamic susceptibility contrast MRI (DSC-MRI) is usually overestimated. One solution is to calibrate DSC-MRI CBF using a complementary CBV method. In this study, T1-based CBV (Bookend) and VASO were used to calibrate CBF from DSC-MRI, and results from calibrations were compared with CBF from pseudo-continuous ASL (pCASL). Both calibration methods showed absolute grey matter CBF values which were comparable with corresponding CBF values from pCASL.