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Abstract #2198

Calibration of Dynamic Susceptibility Contrast MRI Using T1-Based Steady-State CBV (Bookend Technique) and Vascular Space Occupancy (VASO): Comparison with Pseudo-Continuous Arterial Spin Labeling

Emelie Lindgren1, Ronnie Wirestam1, Karin Markenroth Bloch1, 2, Andr Ahlgren1, Matthias J.P. van Osch3, Danielle van Westen4, Yulia Surova5, 6, Freddy Sthlberg1, 7, Linda Knutsson1

1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2Clinical science, Philips, Lund, Sweden; 3C.J.Gorter Center for high field MRI, Department of Radiology, LUMC, Leiden, Netherlands; 4Center for Medical Imaging and Physiology, Skane University Hospital Lund, Lund, Sweden; 5Department of Clinical Sciences, Lund University, Lund, Sweden; 6Department of Neurology, Skne University Hospital, Lund, Sweden; 7Lund University Bioimaging Centrum, Lund University, Lund, Sweden

Quantification of CBF in absolute terms is relevant in some clinical applications. However, absolute CBF obtained by dynamic susceptibility contrast MRI (DSC-MRI) is usually overestimated. One solution is to calibrate DSC-MRI CBF using a complementary CBV method. In this study, T1-based CBV (Bookend) and VASO were used to calibrate CBF from DSC-MRI, and results from calibrations were compared with CBF from pseudo-continuous ASL (pCASL). Both calibration methods showed absolute grey matter CBF values which were comparable with corresponding CBF values from pCASL.