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Abstract #2206

Time-Consistent Non-Rigid Motion Compensation for 3D DCE-MRI of the Entire Liver

Marijn van Stralen1, Hanke J. Schalkx2, Harrit W. Mulder1, Kenneth Coenegrachts3, Maarten S. van Leeuwen2, Wouter B. Veldhuis2, Josien P.W. Pluim1

1Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands; 2Radiology, UMC Utrecht, Utrecht, Netherlands; 3Radiology, AZ St.‐Jan Brugge‐Oostende AV, Brugge, West-Vlaanderen, Belgium

Recent developments have enabled high-resolution dynamic contrast-enhanced MRI (DCE-MRI) of the entire liver. However, breathing and other organ motion hampers the current clinical use of DCE-MRI for perfusion analysis. Moreover, intensity change as a result of contrast perfusion challenges existing motion correction techniques. We propose a temporally consistent motion compensation method based on the integrated 3D + time alignment of the gradient magnitude of the image intensity. It is shown that time-consistent non-rigid registration outperforms temporal independent registration by measuring surface errors on manual liver segmentations. These results promise improved perfusion analysis (eg. pharmacokinetic modeling) of abdominal organs using DCE-MRI.