Segmentation of Normal Liver Volume Using Dynamic Contrast Enhanced Gd-EOB-DTPA Time Intensity Curves

Jonathan P. Dyke¹, Pascal Spincemaille¹, Martin R. Prince¹, Krishna Juluru¹

Monitoring total liver volume is of importance to assess regeneration post-resection. Normal liver volume is also of prognostic importance in subject with tumor burden and inflammatory disease. A technique is presented to segment normal liver by calculating a voxel wise Pearsons R2 correlation coefficient with slice specific Gd-EOB-DTPA (Eovist) dynamic contrast enhanced DCE-MRI uptake curves. Significant correlation was found with DCE segmented liver volume and manual tracing methods. Future application of this technique may be found in other organ systems and patient specific monitoring of organ volume over time.