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Abstract #2219

Assessment of Vessel Permeability by Combining DCE and ASL MRI

Ting-Ting Chang1, Alex M. Wong2, Feng-Xian Yan1, Yu-Shi Lin1, Ho-Ling Liu1, 2

1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; 2Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

This study proposed to combine dynamic contrast enhanced (DCE) and arterial spin labeling (ASL) MRI for assessing tumor vessel permeability in a group of 11 pediatric patients. After co-registration of measured parametric maps, permeability-surface-product (PS) was calculated by Ktrans from DCE-MRI and CBF from ASL on voxel-by-voxel basis. The results showed that for small Ktrans values they were approximately equal to the resulted PS values. When Ktrans values were greater, they became increasingly underestimated than the PS values. The largest discrepancy between Ktrans and PS in this study was 13% in a patient with mean tumor Ktrans of 0.10 min-1.