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Abstract #2220

Dynamic Contrast-Enhanced MRI of Mouse Cirrhotic Liver: A Pilot Study

Septian Hartono1, 2, Tong San Koh1, Lei Zhou3, Quan Sing Ng1, Puor Sherng Lee1, Kai-Hsiang Chuang4, Yock Young Dan3, Laurent Martarello5, Choon Hua Thng1

1National Cancer Centre Singapore, Singapore, NA, Singapore; 2Nanyang Technological University, Singapore, NA, Singapore; 3National University Health System, Singapore, NA, Singapore; 4Singapore Bioimaging Consortium, Singapore, NA, Singapore; 5Roche Translational Medicine Hub, Singapore, NA, Singapore

We carried out a pilot study using DCE-MRI to assess liver cirrhosis in mice. Elevated values of extravasation parameters such as interstitial volume and vascular permeability were found in the cirrhotic mice, which was consistent to the capillarisation of liver sinusoidal endothelium found in liver cirrhosis.