Septian Hartono1,
2, Tong San Koh1, Lei Zhou3, Quan Sing Ng1,
Puor Sherng Lee1, Kai-Hsiang Chuang4, Yock Young Dan3,
Laurent Martarello5, Choon Hua Thng1
1National
Cancer Centre Singapore, Singapore, NA, Singapore; 2Nanyang
Technological University, Singapore, NA, Singapore; 3National
University Health System, Singapore, NA, Singapore; 4Singapore
Bioimaging Consortium, Singapore, NA, Singapore; 5Roche
Translational Medicine Hub, Singapore, NA, Singapore
We carried out a pilot study using DCE-MRI to assess liver cirrhosis in mice. Elevated values of extravasation parameters such as interstitial volume and vascular permeability were found in the cirrhotic mice, which was consistent to the capillarisation of liver sinusoidal endothelium found in liver cirrhosis.
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