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Abstract #2223

Correlation Between Hemodynamic Variation and Resting-State fMRI in Patients with Carotid Artery Stenosis

Feng-Xian Yan1, Tsong-Hai Lee2, Pin-Hsun Huang1, Kuo-Lun Huang2, Ho-Fai Wong3, Ho-Ling Liu1, 3

1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 2Department of Neurology and Stroke Center, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan; 3Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

This study aimed to investigate whether the functional connectivity (FC) derived from BOLD signal fluctuation is correlated with deficient blood supply in patients with unilateral internal carotid artery (ICA) stenosis. Thirty-eight patients underwent resting-state (RS) fMRI and DSC perfusion MRI scans. This study found that the prolonged perfusion delay time (Tmax) was significantly correlated (p < 0.05) with reduced default-mode network connectivity in the inferior parietal cortex ipsilateral to the ICA stenosis without apparent CBF impairments. Further studies are required to understand whether such correlation is originated from neuronal or purely hemodynamic variations.