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Abstract #2224

The Comparison Study of ASL and DCE MRI for Renal Glomerular Filtration Rate (GFR) Mapping

Jing Wang1, Yudong Zhang2, Jue Zhang1, Xiaoying Wang3, Jing Fang4

1Academy for Advanced Interdisciplinary Studies, Peking Unversity, Beijing, China; 2Department of Radiology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China, Beijing, China; 3Department of Radiology, Peking University First Hospital, Beijing, China; 4Peking University, Beijing, China

This study developed a new approach for noninvasive renal perfusion and glomerular filtration rate mapping based on PASL using variable TE acquisitions on clinical 3T MR. There were six rabbits included in the initial experiments and each of them accepted 6 different TEs ASL scans. Based on the proposed method, the rabbit RBF, blood R2* and GFR maps were obtained simultaneously by a two-compartment model fitting. Furthermore, the non-contrast GFR values were compared with DCE-MRI results to explore the feasibility of VTE-ASL as a noninvasive assessment of renal status in a single examination.