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Abstract #2225

Direct CBF Comparison Between MRI ASL and DSC and Perfusion CT-Scan in Treated Tumor Patients

Marjorie Villien1, 2, Do Kien N Guyen1, Julien Bouvier1, Cedric Mendoza3, Sylvie Grand3, Louise Fanchon1, Emmanuel Luc Barbier4, Irne Troprs5, Jean-Franois Le Bas3, Alexandre Krainik3, Jan M. Warnking1

1Grenoble Institut of Neurosciences, INSERM, Grenoble, France; 2Massachusetts General Hospital, Harvard, Charlestown, MA, United States; 3Clinique universitaire de neuroradiologie et d'IRM, CHU Grenoble, Grenoble, France; 4Grenoble Institut of Neurosciences, INSERM U836, Grenoble, France; 5SFR1, Universit Joseph Fourier, Grenoble, France

The goals of this study were to assess the reproducibility of Dynamic Susceptibility Contrast (DSC) MRI and Perfusion-CT (PCT) and to compare the CBF estimates obtained with DSC, PCT, and Arterial Spin Labeling (ASL). We included patients with cerebral tumor, routinely monitored with these imaging methods. We observed good agreement between DSC and PCT, and poor correlation between DSC and ASL. A more detailed analysis of the present data could yield insights into the respective strengths and weaknesses of each method depending on the vascular properties.