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Abstract #2251

Resting-State fMRI Signal Anti-Correlation Exists in Absence of Global Signal Regression

Xiao Liu1, Jeff H. Duyn1

1Advanced MRI section, LFMI, NINDS, National Institutes of Health, Bethesda, MD, United States

To understand the negative correlation between resting-state fMRI signals and how it could be affected by global signal regression (GSR) procedure, a novel technique was applied to temporally decompose the default mode network (DMN) into multiple co-activation patterns (CAPs). This decomposition of activity patterns during rest suggests that anti-correlation between brain regions is not an artifact of global signal regression but may be caused by brief periods of negatively correlated neuronal activity.