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Abstract #2252

Spontaneous Low-Frequency Functional Connectivity and Temporal Dynamics: Working Memory Vs. Rest

Jingyuan Chen1, Catie Chang2, Gary H. Glover1, 3

1Electrical Engineering, Stanford University, Palo Alto, CA, United States; 2National Institutes of Health, Bethesda, MD, United States; 3Radiology Department, Stanford University, Palo Alto, CA, United States

In the current study, we compared the spontaneous temporal behavior of the default-mode network (DMN) at rest and under a sustained 2-back working memory (WM) task load. Results indicated that during sustained WM task: (1) the spontaneous low-frequency temporal connectivity showed similar patterns as the steady-state task-induced activation/deactivation; (2) global variability with posterior cingulate cortex was weaker compared to rest; (3) the DMN and salience network showed significant power reduction compared to rest.